An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
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چکیده
منابع مشابه
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans. While a wild-type TAC1 allele drives high expression of CDR1/2 in response to inducers, we showed previously that TAC1 can be hyperactive by a gain-of-function (GOF) point mutation responsible for constitutive high expressi...
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Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces.
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2008
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2008.06176.x